Fig. 4
- ID
- ZDB-FIG-150422-43
- Publication
- Mackay et al., 2015 - Vitamin K reduces hypermineralisation in zebrafish models of PXE and GACI
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Vitamin K reduces hypermineralisation in gräte and dragonfish mutants. (A) Representative images of grt-/- embryos after treatment with vitamin K or warfarin from 4-8dpf, showing that vitamin K reduces hypermineralisation, whereas warfarin exacerbates it. (B,C) Quantification of Alizarin Red staining in A reveals significant rescue of the phenotype by vitamin K (n = 20 embryos per group). (D) Dgf-/- embryos treated with vitamin K or warfarin from 4-8dpf. (E,F) Quantification of Alizarin Red staining in D reveals a significant beneficial effect of vitamin K; results are similar to those seen in grt-/- embryos (n = 24 per group). (G) Alizarin Red staining of dgf-/- embryos exhibiting ectopic mineralisation in the ventral skin. Administration of vitamin K did not affect the incidence (H) or the extent (I) of this mineralisation. |
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Stage: | Days 7-13 |