FIGURE

Fig. 4

ID

ZDB-FIG-150421-7

Publication

Navis et al., 2015 - Loss of cftr function leads to pancreatic destruction in larval zebrafish

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Fig. 4

Timecourse of pancreatic destruction incftr mutants. (A and B) Transverse section of Tg(ptf1a:GFP) expression marking the acinar cells in (A) WT and (B) cftr mutant samples. (C and D) Transverse section at 14 dpf of (C) WT and (D) cftr mutant pancreas marked by ela:GFP expression. (E and F) Transverse section of (E) WT and (F) cftr mutant samples expressing ela:GFP in the acini demonstrating loss of pancreatic acinar tissue at 16 dpf. (G and H) Transverse section of (G) WT and (H) cftr mutant samples expressing ela:GFP in the pancreas at 22 dpf with severe pancreatic destruction. Arrow indicates absent acinar tissue. Scale bars=50 µm.

Expression Data

Genes:	DsRed EGFP
Fish:	gz15Tg jh1Tg cftr^{pd1049/pd1049}; gz15Tg cftr^{pd1049/pd1049}; jh1Tg
Anatomical Terms:	liver pancreatic acinar cell
Stage Range:	Days 7-13 to Days 21-29

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cftr^{pd1049/pd1049}; gz15Tg
Observed In:	pancreas pancreatic acinar cell
Stage Range:	Days 14-20 to Days 21-29

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 399(2), Navis, A., Bagnat, M., Loss of cftr function leads to pancreatic destruction in larval zebrafish, 237-48, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.