ZFIN ID: ZDB-FIG-150421-8
Navis et al., 2015 - Loss of cftr function leads to pancreatic destruction in larval zebrafish. Developmental Biology   399(2):237-48 Full text @ Dev. Biol.
Observed In:
Stage: Adult

Fig. 5

Adult cftr mutants undergo severe pancreatic destruction. (A and B) Transverse section of (A) WT and (B) cftrpd1049 mutant pancreas expressing ela:GFP in acinar cells. (C and D) Transverse section of 3 month post fertilization (mpf) WT and cftr mutant pancreas stained for insulin and glucagon to mark the pancreatic islets. (E–H) Hematoxylin and eosin staining of WT and cftr mutant pancreatic sections at (E and F) 3 mpf and (G and H) 1 year post fertilization. (I and J) Period Acid Schiff staining of 3 mpf transverse sections of the pancreas indicating mucus within the lumen of the pancreatic duct. Arrows indicate dilated pancreatic ducts. ib: intestinal bulb, p: pancreas, l: liver. Scale bars=50 µm.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
cftrpd1049/pd1049(AB) standard conditions Adult exocrine pancreas central region lacks all parts of type pancreatic acinar cell, abnormal
Adult exocrine pancreas fibrillary, abnormal
Adult pancreas degenerate, abnormal
Adult pancreatic duct dilated, abnormal
Adult pancreatic duct obstructed, abnormal
cftrpd1049/pd1049; gz15Tg; m1018Tg standard conditions Adult exocrine pancreas degenerate, abnormal
Adult islet decreased size, abnormal
Adult islet disorganized, abnormal
Adult islet increased amount, abnormal
Adult pancreas morphology, abnormal
Adult pancreatic acinar cell decreased amount, abnormal
ZFIN wishes to thank the journal Developmental Biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Developmental Biology, 399(2), Navis, A., Bagnat, M., Loss of cftr function leads to pancreatic destruction in larval zebrafish, 237-48, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.