FIGURE

Fig. 5

ID

ZDB-FIG-150421-8

Publication

Navis et al., 2015 - Loss of cftr function leads to pancreatic destruction in larval zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Adult cftr mutants undergo severe pancreatic destruction. (A and B) Transverse section of (A) WT and (B) cftr^pd1049 mutant pancreas expressing ela:GFP in acinar cells. (C and D) Transverse section of 3 month post fertilization (mpf) WT and cftr mutant pancreas stained for insulin and glucagon to mark the pancreatic islets. (E–H) Hematoxylin and eosin staining of WT and cftr mutant pancreatic sections at (E and F) 3 mpf and (G and H) 1 year post fertilization. (I and J) Period Acid Schiff staining of 3 mpf transverse sections of the pancreas indicating mucus within the lumen of the pancreatic duct. Arrows indicate dilated pancreatic ducts. ib: intestinal bulb, p: pancreas, l: liver. Scale bars=50 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	cftr^{pd1049/pd1049} (AB) cftr^{pd1049/pd1049}; gz15Tg; m1018Tg
Observed In:	exocrine pancreas exocrine pancreas central region islet pancreas pancreatic acinar cell pancreatic duct
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 399(2), Navis, A., Bagnat, M., Loss of cftr function leads to pancreatic destruction in larval zebrafish, 237-48, Copyright (2015) with permission from Elsevier. Full text @ Dev. Biol.