FIGURE

Fig. 6

ID

ZDB-FIG-150413-13

Publication

Ma et al., 2015 - Jag1b is essential for patterning inner ear sensory cristae by regulating anterior morphogenetic tissue separation and preventing posterior cell death

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Fig. 6

MAPK pathway inhibition blocks the separation of the anterior and lateral cristae. (A-L′) MAPKK inhibition represses expression of p-Erk3 and E-cadherin in both jag1b^+/- and jag1b^-/- embryos. Arrows and arrowheads indicate staining of E-Cadherin or p-Erk3. (M-M′′) In jag1b^+/- embryos, treatment with the MAPKK inhibitors CI-1040 (M′) and PD0325901 (M′′) blocks separation of the anterior and lateral cristae. (N-N′′) In jag1b^-/- embryos, the MAPKK inhibitors CI-1040 (N′) and PD0325901 (N′′) block the morphological change of cells in the anterior prosensory domain. Dorsolateral views. Scale bars: 20µm. Anterior towards the left and dorsal upwards.

Expression Data

Genes:	cdh1 EGFP mapk6
Fish:	jag1b^gd2Gt/gd2Gt jag1b^gd2Gt/+
Condition:	chemical treatment: pharmaceutical
Anatomical Term:	otic vesicle
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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