Gene

th

ID
ZDB-GENE-990621-5
Name
tyrosine hydroxylase
Symbol
th Nomenclature History
Previous Names
  • th1 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
312 figures from 167 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
ion27dTgTransgenic insertionIntron 12UnknownDNA and CRISPR
ion32TgTransgenic insertionIntron 12UnknownDNA and CRISPR
ion59dTgTransgenic insertionUnknownUnknownDNA and CRISPR
m1512TgTransgenic insertionUnknownUnknownDNA and CRISPR
m1513TgTransgenic insertionUnknownUnknownDNA and CRISPR
m1514TgTransgenic insertionUnknownUnknownDNA and CRISPR
sa1635Allele with one point mutationUnknownSplice SiteENU
sa38085Allele with one point mutationUnknownSplice SiteENU
zf2193TgTransgenic insertionUnknownUnknownDNA and CRISPR
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Sequence Targeting Reagents
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Human Disease
Associated With th Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Segawa syndrome, recessive 605407
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Associated With th Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
Conserved_site IPR021164 Tyrosine hydroxylase, conserved site
Domain IPR019774 Aromatic amino acid hydroxylase, C-terminal
Domain IPR041903 Tyrosine 3-monooxygenase, catalytic domain
Domain IPR049321 Tyrosine 3-monooxygenase-like, ACT domain
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Domain Details Per Protein
Protein Length ACT-like domain Aromatic amino acid hydroxylase Aromatic amino acid hydroxylase, C-terminal Aromatic amino acid hydroxylase, iron/copper binding site Aromatic amino acid hydroxylase superfamily Aromatic amino acid monoxygenase, C-terminal domain superfamily Tyrosine 3-monooxygenase Tyrosine 3-monooxygenase, catalytic domain Tyrosine 3-monooxygenase-like Tyrosine 3-monooxygenase-like, ACT domain Tyrosine hydroxylase, conserved site
UniProtKB:B3DJW5 489
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 25
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA ottdart00000002329 (1) Havana 1,226 nt
mRNA th-201 (1) Ensembl 1,470 nt
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Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab8-th Rabbit
  • WB
1
ab7-th IgY Chicken
  • IHC
  • WB
3
Ab5-th monoclonal IgG2a , k Mouse
  • IHC
Vector Laboratories
3
Ab3-th monoclonal IgG1 , k Mouse
  • IHC
  • WB
Millipore
Antibodies-online.com
117
Ab4-th polyclonal Rabbit
  • IHC
  • WB
Millipore
48
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Plasmids
Constructs
Construct Regulatory Region Coding Sequence Species Tg Lines Citations
Tg2(th:GAL4-VP16)
  • th
  • Danio rerio
1Ilin et al., 2021
Tg(-12th:GFP)
  • th
  • Danio rerio
1 (5)
TgBAC(th:Cre,myl7:Cerulean)
  • Danio rerio
1Förster et al., 2017
Tg(LOXP-th-LOXP)
    • Danio rerio
    1Gu et al., 2020
    Tg(th:EGFP)
    • th
    • Danio rerio
    Zebrafish Nomenclature Committee
    Tg(th:GAL4-VP16)
    • th
    • Danio rerio
    1 (6)
    Tg(th:GFP)
    • th
    • Danio rerio
    1 (2)
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    Marker Relationships
    Relationship Marker Type Marker Accession Numbers Citations
    Contained inBACCH211-220G18ZFIN Curated Data
    Contained inBACIZAB-12K13
    EncodescDNAMGC:194326ZFIN Curated Data
    EncodescDNAMGC:194338ZFIN Curated Data
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    Sequences
    Orthology
    Comparative Orthology
    Alliance
    Gene Tree
    Ensembl
    Species Symbol Chromosome Accession # Evidence
    HumanTH11
    Conserved genome location (synteny) (2)
    Amino acid sequence comparison (2)
    MouseTh7
    Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Citations
    1 - 10 of 319
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