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Gene

th

ID
ZDB-GENE-990621-5
Name
tyrosine hydroxylase
Symbol
th Nomenclature History
Previous Names
  • th1 (1)
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
271 figures from 135 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With th Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Segawa syndrome, recessive 605407
Associated With th Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
Conserved_site IPR021164 Tyrosine hydroxylase, conserved site
Domain IPR019774 Aromatic amino acid hydroxylase, C-terminal
Domain IPR041903 Tyrosine 3-monooxygenase, catalytic domain
Family IPR001273 Aromatic amino acid hydroxylase
Family IPR005962 Tyrosine 3-monooxygenase
Family IPR019773 Tyrosine 3-monooxygenase-like
Homologous_superfamily IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamily
Homologous_superfamily IPR036951 Aromatic amino acid hydroxylase superfamily
Domain Details Per Protein
Protein Length Aromatic amino acid hydroxylase Aromatic amino acid hydroxylase, C-terminal Aromatic amino acid hydroxylase, iron/copper binding site Aromatic amino acid hydroxylase superfamily Aromatic amino acid monoxygenase, C-terminal domain superfamily Tyrosine 3-monooxygenase Tyrosine 3-monooxygenase, catalytic domain Tyrosine 3-monooxygenase-like Tyrosine hydroxylase, conserved site
UniProtKB:Q6ZM47 408
UniProtKB:Q9W7K7 110
UniProtKB:A0A2R8RPJ0 505
UniProtKB:B3DJW5 489
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab8-th Rabbit
  • WB
1
ab7-th IgY Chicken
  • IHC
  • WB
2
Ab5-th monoclonal IgG2a , k Mouse
  • IHC
Vector Laboratories
3
Ab3-th monoclonal IgG1 , k Mouse
  • IHC
  • WB
Millipore
Antibodies-online.com
105
Ab4-th polyclonal Rabbit
  • IHC
  • WB
Millipore
34
Ab1-th monoclonal IgG1 Mouse
  • IHC
  • WB
ImmunoStar, Inc.
40
Ab2-th polyclonal Rabbit
  • IHC
Pel-Freez Biologicals
12
Ab6-th polyclonal Rabbit
  • IHC
16
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations