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ZIRC
ZFIN ID: ZDB-GENE-990621-5
Gene Name: tyrosine hydroxylase
Gene Symbol: th
Sequence Ontology ID : SO:0000704

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Previous Name: th1 (1)

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
AUTOMATED DESCRIPTION
Exhibits tyrosine 3-monooxygenase activity. Involved in dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to localize to the axon; cytoplasm; and perikaryon. Human  ...
GENE EXPRESSION
All Expression Data: 254 figures from 123 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ion27Tg Transgenic Insertion Intron 12 Unknown DNA_AND_CRISPR
ion32Tg Transgenic Insertion Intron 12 Unknown DNA_AND_CRISPR
sa1635 Point Mutation Unknown Splice Site ENU
sa38085 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH th HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Segawa syndrome, recessive 605407
    DISEASE ASSOCIATED WITH th VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process catecholamine biosynthetic process (more)
    Cellular Component axon (more)
    Molecular Function tyrosine 3-monooxygenase activity (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002329 (1) 1226
    th-201 (1) 1470
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    MARKER RELATIONSHIPS
    thContained in: [BAC] CH211-220G18 (1) (order this), IZAB-12K13
    thEncodes: [cDNA] MGC:194326 (1) (order this), MGC:194338 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131149 (1) 1470bp
    Genomic GenBank:AL954320 (1) 215130bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8RPJ0 (1) 505aa
    Sequence Clusters UniGene:88609 (1)
    Sequence Information (all 22)
    ORTHOLOGY for th (Chr: 25)
    CITATIONS (215)