Gene
th
- ID
- ZDB-GENE-990621-5
- Name
- tyrosine hydroxylase
- Symbol
- th Nomenclature History
- Previous Names
-
- th1 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables tyrosine 3-monooxygenase activity. Acts upstream of or within dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 312 figures from 167 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
ion27dTg | Transgenic insertion | Intron 12 | Unknown | DNA and CRISPR | |
ion32Tg | Transgenic insertion | Intron 12 | Unknown | DNA and CRISPR | |
ion59dTg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
m1512Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
m1513Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
m1514Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
sa1635 | Allele with one point mutation | Unknown | Splice Site | ENU | |
sa38085 | Allele with one point mutation | Unknown | Splice Site | ENU | |
zf2193Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR |
1 - 9 of 9
Show
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-th | (2) | |
CRISPR2-th | (2) | |
CRISPR3-th | Kleinstiver et al., 2015 | |
CRISPR4-th | Feng et al., 2016 | |
CRISPR5-th | (9) | |
CRISPR6-th | Yang et al., 2018 | |
CRISPR7-th | Gu et al., 2020 | |
CRISPR8-th | Gu et al., 2020 | |
CRISPR9-th | Gu et al., 2020 | |
MO1-th | N/A | Formella et al., 2012 |
1 - 10 of 17
Show
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Segawa syndrome, recessive | 605407 |
1 - 1 of 1
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR018301 | Aromatic amino acid hydroxylase, iron/copper binding site |
Conserved_site | IPR021164 | Tyrosine hydroxylase, conserved site |
Domain | IPR019774 | Aromatic amino acid hydroxylase, C-terminal |
Domain | IPR041903 | Tyrosine 3-monooxygenase, catalytic domain |
Domain | IPR049321 | Tyrosine 3-monooxygenase-like, ACT domain |
1 - 5 of 11 Show all
Domain Details Per Protein
Protein | Length | ACT-like domain | Aromatic amino acid hydroxylase | Aromatic amino acid hydroxylase, C-terminal | Aromatic amino acid hydroxylase, iron/copper binding site | Aromatic amino acid hydroxylase superfamily | Aromatic amino acid monoxygenase, C-terminal domain superfamily | Tyrosine 3-monooxygenase | Tyrosine 3-monooxygenase, catalytic domain | Tyrosine 3-monooxygenase-like | Tyrosine 3-monooxygenase-like, ACT domain | Tyrosine hydroxylase, conserved site |
---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:B3DJW5
|
489 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA | ottdart00000002329 (1) | Havana | 1,226 nt | ||
mRNA |
th-201
(1)
|
Ensembl | 1,470 nt |
1 - 2 of 2
Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
ab8-th | Rabbit |
|
1 | ||||
ab7-th | IgY | Chicken |
|
3 | |||
Ab5-th | monoclonal | IgG2a , k | Mouse |
|
Vector Laboratories
|
3 | |
Ab3-th | monoclonal | IgG1 , k | Mouse |
|
Millipore
Antibodies-online.com |
117 | |
Ab4-th | polyclonal | Rabbit |
|
Millipore
|
48 |
1 - 5 of 8 Show all
Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg2(th:GAL4-VP16) |
|
| 1 | Ilin et al., 2021 | |
Tg(-12th:GFP) |
|
| 1 | (5) | |
TgBAC(th:Cre,myl7:Cerulean) |
|
| 1 | Förster et al., 2017 | |
Tg(LOXP-th-LOXP) |
|
| 1 | Gu et al., 2020 | |
Tg(th:EGFP) |
|
| Zebrafish Nomenclature Committee | ||
Tg(th:GAL4-VP16) |
|
| 1 | (6) | |
Tg(th:GFP) |
|
| 1 | (2) |
1 - 7 of 7
Show
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-220G18 | ZFIN Curated Data | |
Contained in | BAC | IZAB-12K13 | ||
Encodes | cDNA | MGC:194326 | ZFIN Curated Data | |
Encodes | cDNA | MGC:194338 | ZFIN Curated Data |
1 - 4 of 4
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131149 (1) | 1470 nt | ||
Genomic | GenBank:AL954320 (2) | 215130 nt | ||
Polypeptide | UniProtKB:B3DJW5 (1) | 489 aa |
- Chen, Y.C., Martins, T.A., Marchica, V., Panula, P. (2024) Angiopoietin 1 and integrin beta 1b are vital for zebrafish brain development. Frontiers in Cellular Neuroscience. 17:12897941289794
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Kim, T.Y., Roychaudhury, A., Kim, H.T., Choi, T.I., Baek, S.T., Thyme, S.B., Kim, C.H. (2024) Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536. Translational psychiatry. 14:8282
- Miyazaki, S., Shimizu, N., Miyahara, H., Teranishi, H., Umeda, R., Yano, S., Shimada, T., Shiraishi, H., Komiya, K., Katoh, A., Yoshimura, A., Hanada, R., Hanada, T. (2024) DHCR7 links cholesterol synthesis with neuronal development and axonal integrity. Biochemical and Biophysical Research Communications. 712-713:149932149932
- Roychaudhury, A., Lee, Y.R., Choi, T.I., Thomas, M.G., Kahn, T.N., Yousaf, H., Skinner, C., Maconachie, G., Crosier, M., Horak, H., Constantinescu, C.S., Kim, T.Y., Lee, K.H., Kyung, J.J., Wang, T., Ku, B., Chodirker, B.N., Hammer, M.F., Gottlob, I., Norton, W.H.J., Gorlei, R., Kim, H.G., Graziano, C., Pippucci, T., Lovino, E., Montanari, F., Severi, G., Toro, C., Boerkoel, C.F., Cha, H.S., Choi, C.Y., Kim, S., Yoon, J.Y., Gilmore, K., Vora, N.L., Davis, E.E., Chudley, A.E., Schwartz, C.E., and Kim, C.H. (2024) SRPK3 Is Essential for Cognitive and Ocular Development in Humans and Zebrafish, Explaining X-Linked Intellectual Disability. Annals of neurology. 96(5):914-931
- Ruan, D.D., Zou, J., Liao, L.S., Ji, M.D., Wang, R.L., Zhang, J.H., Zhang, L., Gao, M.Z., Chen, Q., Yu, H.P., Wei, W., Li, Y.F., Li, H., Lin, F., Luo, J.W., Lin, X.F. (2024) In vitro study of ATP1A3 p.Ala275Pro mutant causing alternating hemiplegia of childhood and rapid-onset dystonia-parkinsonism. Frontiers in neuroscience. 18:14155761415576
- Wang, H., Li, X., Li, J., Yu, F., Li, Q., Qin, M., Gui, L., Qian, Y., Huang, M. (2024) Long-term exposure to ionic liquid [C8mim]Br induces the potential risk of anxiety and memory deterioration through disturbing neurotransmitter systems. Neurotoxicology. 104:66-74
- Zhang, Q., Li, F., Li, T., Lin, J., Jian, J., Zhang, Y., Chen, X., Liu, T., Gou, S., Zhang, Y., Liu, X., Ji, Y., Wang, X., Li, Q. (2024) Nomo1 deficiency causes autism-like behavior in zebrafish. EMBO reports. 25(2):570-592
- Altbürger, C., Holzhauser, J., Driever, W. (2023) CRISPR/Cas9-based QF2 knock-in at the tyrosine hydroxylase (th) locus reveals novel th-expressing neuron populations in the zebrafish mid- and hindbrain. Frontiers in Neuroanatomy. 17:11968681196868
- Araujo-Silva, H., de Souza, A.M., Mamede, J.P.M., Batistuzzo de Medeiros, S.R., Luchiari, A.C. (2023) Individual differences in response to alcohol and nicotine in zebrafish: gene expression and behavior. Development, growth & differentiation. 65(8):434-445
1 - 10 of 319
Show