FIGURE

Fig. 5

ID

ZDB-FIG-150402-22

Publication

Wan et al., 2014 - Retinal Injury, Growth Factors, and Cytokines Converge on β-Catenin and pStat3 Signaling to Stimulate Retina Regeneration

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

HB-EGF and IL-11 Synergize with Each Other to Stimulate MG Proliferation and Activation of the Stat3 and β-Catenin Signaling Components in the Uninjured Retina

(A and B) HB-EGF and IL-11 synergize with each other to stimulate the generation of BrdU⁺ progenitors and the accumulation of Stat3 (A) and β-catenin (B) signaling components in the uninjured retina of gfap:stat3-gfp transgenic fish. Arrows point to double-labeled cells. Scale bar represents 50 µm. The green immunofluorescence signal in the photoreceptor layer is nonspecific, since it does not show up when using a secondary antibody coupled to a red Fluor (Figure S7).

(C–E) Quantification of BrdU⁺ (C), Stat3-GFP⁺ (D), and β-catenin⁺ (E) progenitors in retinas intravitreally injected with HB-EGF, IL-11, or HB-EGF/IL-11. Error bars represent SD; n = 3.