Fig. 5
- ID
- ZDB-FIG-150224-11
- Publication
- Berger et al., 2014 - Loss of tropomodulin4 in the zebrafish mutant träge causes cytoplasmic rod formation and muscle weakness reminiscent of nemaline myopathy
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The tmod4trg skeletal muscle has impaired force generation. (A) Peak active force at optimal length in tmod4trg is significantly lower than that of siblings (n=6). (B) During single-twitch contraction, the half-time (t1/2) of contraction is similar in tmod4trg and siblings, however, the relaxation time is significantly prolonged in tmod4trg (n=6). (C) Length–active force curves show steeper ascending limb in tmod4trg (red) than in siblings (blue) (n=5). Force is normalised to the maximal active force at optimal length (Lopt), and length is normalised to Lopt. Data are means ± s.e.m., **P<0.01, ***P<0.001. |
Fish: | |
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Observed In: | |
Stage: | Day 5 |