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ZIRC
ZFIN ID: ZDB-FIG-141218-12
Krauss et al., 2013 - transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival. Biology Open   2(7):703-710 Full text @ Biol. Open
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Day 5 to Adult

Fig. 1

transparent mutants show a reduction in iridophore pigmentation. (A,C,D) Wild type and (B,E-H) tra mutants. At 5 dpf, mutant larvae show strong reduction in iridophores in dorsal and ventral positions (B) as compared to wild type (A). Arrows in panels A and B highlight the appearance and position of iridophores in larvae. No other defects are apparent. Two months old wild type animals (C) present a fully developed pigment pattern, while tra individuals (E) developed only few iridophores, visible between the dark stripes. (G) Close-up of the region boxed in panel E. At that age, melanophores are reduced in number in the mutants, however, the typical four stripes developed. While the mutant fish grow, the melanophore stripes break up into spots (F, close up in H), compare six months old tra mutant (F) to wild type (D) of the same age. The abdominal cavity, typically covered by a thick sheet of iridophores in wild type, lacks this cell type in tra mutants. Iridophores of the eyes are strongly reduced throughout life in the mutants. Pigment patterning of fins and scales appear normal. Scale bars: 0.5 mm (A,B); 1 mm (C,E), 3 mm (D,F).

Gene Expression DetailsNo data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
mpv17b18/b18 standard conditions Day 5 eye iridophore decreased amount, abnormal
Day 5 iridophore decreased amount, abnormal
Day 5 melanocyte normal amount, normal
Day 5 melanocyte position, normal
Day 5 xanthophore normal amount, normal
Day 5 xanthophore position, normal
Days 45-89 eye iridophore decreased amount, abnormal
Days 45-89 iridophore decreased amount, abnormal
Days 45-89 melanocyte decreased amount, abnormal
Adult anal fin melanophore stripe normal amount, normal
Adult caudal fin melanophore stripe normal amount, normal
Adult eye iridophore decreased amount, abnormal
Adult iridophore decreased amount, abnormal
Adult melanocyte decreased amount, abnormal
Adult melanophore stripe distributed, abnormal
Adult trunk melanophore stripe decreased amount, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Biology Open for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Biol. Open