FIGURE

Fig. 3

ID

ZDB-FIG-141023-12

Publication

Alexander et al., 2014 - Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton

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Fig. 3

Requirements for Wnt signaling in pharyngeal arch cell proliferation.

(A–L) Whole mount ISH for pcna in embryos fixed at 3–22 hours post-heat shock (hphs), lateral views, anterior to the left (all heat shocked at 22 hpf). (A–D) pcna is expressed throughout arches, brain and eyes. (E–H) dkk1+ embryos have reduced pcna expression at 3 hphs (E), severe reductions at 6 hphs (F) and virtually no arch expression at 8 hphs (G), before expression returns at 22 hphs (H). (I–L) dntcf3+ embryos show reduced pcna expression at 3 hphs (I), and virtually no expression at 6 hphs (J, K) before expression rebounds between 8–22 hphs (L). (M) Histogram quantifying percentages of dkk1+ and dntcf3+ embryos with moderate versus severe reductions in pcna expression. Scale bar: 100 µm.

Expression Data

Gene:	pcna
Fish:	WT w32Tg/w32Tg w26Tg/+
Condition:	heat shock
Anatomical Terms:	brain eye pharyngeal arch
Stage Range:	Prim-5 to High-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	w32Tg/w32Tg w26Tg/+
Condition:	heat shock
Observed In:	pharyngeal arch cell population proliferation
Stage Range:	Prim-5 to High-pec

Phenotype Detail

Acknowledgments

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