FIGURE

Fig. 2

ID

ZDB-FIG-141023-11

Publication

Alexander et al., 2014 - Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton

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Fig. 2

Requirements for Wnt signaling in craniofacial cartilage development.

(A–C, F, G) Alcian blue stained cartilage at 96 hpf, dissected and flat mounted, ventral views, anterior to the left. (A) Wild-type control, (B) dkk1^+/ heterozygote, (C) dkk1^+/+ homozygote, (F) dntcf3^+/ heterozygote, (G) dntcf3^+/+ homozygote, heat shocked as described (see Results). Arrowheads indicate clefting of Meckel′s cartilage (Mc). (D) Histogram quantifying the frequency of Mc defects in dkk1+ embryos heat shocked at different stages from 16–36 hpf. (E) Histogram quantifying average Mc length, p<0.01. (H) Histogram quantifying the frequency of cartilage defects in arches 1 and 2 in dntcf3+ embryos heat shocked at different stages from 16–30 hpf. Abbreviations: Ch, ceratohyal; Hm, hyomandibular; Mc, Meckels; Pq, palatoquadrate; Sy, symplectic. Scale bar: 100 µm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	w26Tg/w26Tg w32Tg/w32Tg w26Tg/+ w32Tg/+
Condition:	heat shock
Observed In:	ceratohyal cartilage hyomandibula Meckel's cartilage palatoquadrate cartilage pharyngeal arch cartilage symplectic
Stage:	Day 4

Phenotype Detail

Acknowledgments

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