ZFIN ID: ZDB-GENE-000210-8
Gene Name: proliferating cell nuclear antigen
Gene Symbol: pcna    Nomenclature History

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Previous Names: cb16 (1), etID36690.10 (1), fa28e03, fb36g03, wu:fa28e03, wu:fb36g03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have DNA polymerase processivity factor activity. Involved in response to activity and response to bacterium. Localizes to nucleus. Is expressed in several structures, including anterior neural tube; head; immature eye; nervous system; and pleuroperitoneal region. Orthologous to human PCNA (proliferating cell nuclear antigen).
Genome Resources: Alliance (1),  Gene:30678 (1),  Ensembl(GRCz11):ENSDARG00000054155 (2)
GENE EXPRESSION
All Expression Data: 129 figures from 76 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2001 [cb16]
Wild-type Stages, Structures: Blastula:512-cell (2.75h-3.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa8962 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pcna
    1
    CRISPR2-pcna
    1
    MO1-pcna N/A 4
    MO2-pcna N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pcna HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Ataxia-telangiectasia-like disorder 2 615919
    DISEASE ASSOCIATED WITH pcna VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to activity (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcna-201 (1)    Ensembl 1445
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-pcna monoclonal IgG2a , k Mouse IHC, WB Sigma-Aldrich
    Santa Cruz Biotechnology, Inc.
    Millipore
    Dako North America, Inc.
    Life Technologies (Invitrogen)
    Cell Signaling Technology, Inc.
    Abcam plc
    Calbiochem
    Vector Laboratories
    224
    Ab4-pcna polyclonal Rabbit IHC Abcam plc
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcna
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(actb2:RFP-pcna) actb2 pcnaRFP Danio rerio 1 1
    tg(hsp70l:cb-pcna-tagrfp) hsp70l CBpcnaTagRFP Danio rerio 0 1
    MARKER RELATIONSHIPS
    pcna Contained in: [BAC] CH211-139N6 (1)
    pcna Encodes: [EST] cb16 (1) (order this), fa28e03, fb36g03 (1)
    [cDNA] MGC:56705 (1), MGC:77707 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131404 (1) 1247 nt
    Genomic GenBank:BX001050 (1) 175495 nt
    Select Tool
    Polypeptide UniProtKB:Q9PTP1 (1) 260 aa
    Sequence Information (all 19)
    ORTHOLOGY for pcna ( Chr: 10 )
    CITATIONS (192)