FIGURE

Fig. 7

ID

ZDB-FIG-141007-97

Publication

Li et al., 2014 - Overexpression of miR-19b Impairs Cardiac Development in Zebrafish by Targeting ctnnb1

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Overexpression of miR-19b alters the expression of cardiac chamber marker genes. Representative images (8 times magnification) of 48 hpf embryos showing the expression of vmhc (A, B, C and D), amhc (E, F, G and H) and cmlc2 (I, J, K and L) by in situ hybridization are shown. After the heart tube has formed, leftward movement of the heart (jogging) is followed by rightward bending of the ventricle (D-looping) in WT embryos (A, E and I) and NC-injected embryos (B, F and J). In contrast, miR-19b mimic-injected embryos exhibited multiple LR defects, including reversed looping (L-looping; D, H and L) and no looping (C, G and K). In the bottom right-hand corner, the number of embryos examined with the representative expression/total number of embryo are presented. Black dashed lines: the midline of the body axis; red arrow: ventricle; blue arrow: atrium.

Expression Data

Genes:	myh6 myh7 myl7
Fish:	WT
Anatomical Terms:	atrium cardiac ventricle heart
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Physiol. Biochem.