FIGURE

Fig. S2

ID

ZDB-FIG-140618-16

Publication

O'Donnell et al., 2014 - Axon degeneration and PGC-1alpha-mediated protection in a zebrafish model of alpha-synuclein toxicity

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Fig. S2

Alpha-synuclein expression does not impair early survival or axonal outgrowth of peripheral sensory neurons. The CREST3:Gal4:UAS:aSyn-2A-GFP transgene was injected into embryos from a previously described stable line (Palanca et al., 2013) expressing DsRed in peripheral sensory neurons (isl1(ss):Gal4-UAS-DsRed). Embryos were imaged every hour between 32 (A) and 44 (B) hours post-fertilization (hpf). Axons grew normally during this time. (C) Cell bodies were counted, and cell survival at 44 hpf was quantified as a percentage of the earlier time point. There was no difference in survival between WT and aSynexpressing cells by 44 hpf (WT: 104.4±2.4% aSyn: 100.7±3.7%; ne13 embryos; P=0.4203).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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