FIGURE

Fig. 6

ID

ZDB-FIG-140618-14

Publication

O'Donnell et al., 2014 - Axon degeneration and PGC-1alpha-mediated protection in a zebrafish model of alpha-synuclein toxicity

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Fig. 6

PGC-1α mitigates aSyn toxicity. (A) Transgenes co-injected to express PGC-1α and aSyn in sensory neurons. (B,C) Cells were imaged between 2 and 3 dpf. (D) PGC-1α prevented cell death in aSyn-expressing cells at 3 dpf (aSyn: 79.36±6.62%; aSyn+PGC-1α: 98.61±0.95%; ne18; *P =0.0129). (E) PGC-1α prevented axonopathy at 2 dpf (aSyn degeneration score: 2.05±0.14; aSyn+PGC-1α: 1.07±0.07; ne15; ***P<0.0001). At 3 dpf, PGC-1α-expressing axons were still protected at a level equivalent to controls (WT degeneration score: 1.42±0.34, n=12 axons in 6 animals; aSyn: 3.05±0.35, n=19 axons in 8 animals; aSyn+PGC-1α: 1.40±0.22; n=10 axons in 5 animals; one-way ANOVA with Newman-Keuls post-test, **P=0.0052). Scale bars: 50 μm. Wild-type and aSyn data were replotted from Fig. 2.

Expression Data

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Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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