FIGURE

Fig. 8

ID

ZDB-FIG-140416-46

Publication

Viringipurampeer et al., 2014 - Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish

Other Figures

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Fig. 8

Effect of RIP signalling inhibitors on pde6c^w59 mutant phenotype at 7 d.p.f. Retinal histology in (a) wild-type (wt), (b) untreated mutant (mt) and (c) mt retina from embryos treated with 100mM necrostatin-1s (N). White arrows in a–c indicate the photoreceptor nuclear layer of the retina. Rip1 labelling (red) in wt retina (d), in mt retina co-localizing with EGFP-expressing cones that are dying (e), and in mt retina treated with necrostatin-1s (f). (g) rip1 labelling in the retina of pde6c^w59 mutant embryos treated with 20μM necrosulfonamide (S). TUNEL labelling in non-transgenic pde6c^w59 mutant embryos (h–k) corresponding to the treatment panels (d–g) above. Scale bar in d=20μm

Expression Data

Gene:	EGFP
Fish:	ucd1Tg pde6c^w59/w59; ucd1Tg
Anatomical Term:	retinal cone cell
Stage:	Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pde6c^w59/w59 pde6c^w59/w59; ucd1Tg
Observed In:	retinal cone cell retinal cone cell cell death
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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