FIGURE

Fig. 2

ID

ZDB-FIG-140411-16

Publication

Ping et al., 2014 - Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

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Fig. 2

WTAP regulates the nuclear speckle localization of METTL3 and METTL14. (A) The graph represents the quantification of three independent dot-blot experiments (raw data were included in Supplementary information, Figure S3A). The y-axis represents the relative intensity of dots relative to that of the control group. P values were calculated using a two-tailed t-test. Error bars represent SD. (B-D) After transfection (48 h) with the indicated fluorescence FAM-labeled siRNA, HeLa cells were fixed and immunostained with the indicated antibodies. DNA was visualized by DAPI. Scale bar, 10 μm. Supportive data were included in Supplementary information, Figure S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-mettl3 WT + MO1-wtap WT + MO1-mettl3 + MO1-wtap
Knockdown Reagents:	MO1-mettl3 MO1-wtap
Observed In:	apoptotic process eye head notochord ventricular system
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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