FIGURE

Fig. 1

ID

ZDB-FIG-140325-1

Publication

Shiau et al., 2013 - An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development

Other Figures

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Fig. 1

Lack of Microglia in nlrc3-like Mutants

(A and B) Live 5 dpf zebrafish larvae were stained by neutral red to visualize microglia in the brain.

(A) Heterozygous st73/+ larva (arrow points to microglia around optic tectum) is shown.

(B) Homozygous st73 larvae have no microglia (arrow). Dorsal views; anterior is to the top.

(C and D) Microglial marker apoe expression at 5 dpf in the brain is shown.

(E and F) Neutral red-stained heterozygous (E) and homozygous mutant (F) shows normal whole-animal morphologies at 5 dpf. Lateral views; anterior is to the left.

(G) Genetic and physical map of the st73 locus.

(H) Sequence chromatogram shows the lesion (asterisks) in the coding sequence of nlrc3-like (LOC100538217).

(I) The st73 mutation introduces a premature stop codon near the 52 end of the open reading frame of nlrc3-like.

See also Figure S1.

Expression Data

Gene:	apoeb
Fish:	nlrc3l^st73/st73 nlrc3l^st73/+
Anatomical Term:	brain microglial cell
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nlrc3l^st73/st73 nlrc3l^st73/+
Observed In:	brain microglia development microglial cell
Stage:	Day 5

Phenotype Detail

Acknowledgments

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