FIGURE

Fig. 7

ID

ZDB-FIG-140325-7

Publication

Shiau et al., 2013 - An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development

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Fig. 7

Exposure of nlrc3-like Heterozygous Embryos to Systemic LPS Challenge Disrupts Microglia Development

(A) Neutral red staining at 3 dpf shows normal formation of microglia in control uninjected nlrc3-like heterozygous embryos. In contrast, many nlrc3-like heterozygous embryos injected with LPS at 1 and 2 dpf have strongly reduced (6–16 microglia) or eliminated (0–5 microglia) microglia.

(B) Bar graph shows the frequency of loss of microglia in nlrc3-like heterozygous fish injected with LPS, compared with little effect on the wild-type siblings.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT nlrc3l^st73/+
Condition:	chemical treatment: lipopolysaccharide
Observed In:	brain microglia development microglial cell
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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