FIGURE

Fig. 2

ID

ZDB-FIG-140314-7

Publication

Bisgrove et al., 1999 - Regulation of midline development by antagonism of lefty and nodal signaling

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Fig. 2

lefty expression during early zebrafish development. (A-P) In situ localization of lft1 and lft2 transcripts at blastula through late somite stages (A,B, animal pole views; C-N, lateral views, dorsal at right; O,P, dorsoanterior views, anterior at left). lft1 and lft2 localize to the blastoderm margin at sphere (A,B) and dome stages (C,D). At shield stage (E,F), and at 90% epiboly (G,H) both genes localize to the dorsal hypoblast; lft1 is also expressed in dorsal forerunner cells (dfc). 1- to 3-somite embryos express both genes in the polster (po) and prechordal plate (pp, I,J); lft1 is uniquely expressed in Kupffer’s vesicle (Kv) (I), lft2 is uniquely expressed in floorplate precursors (fp) (J). At 6-8 somites lft1 expression is maintained (K) while lft2 is downregulated (L). 13-15 somite embryos express lft1 in the posterior notochord and left habenula (arrowhead) (M); lft2 is not expressed (N). 22-24 somite embryos showing lft1 in the anterior notochord (an), left habenula (arrowhead) and left lateral plate mesoderm (lpm) (O); lft2 is expressed in left lateral plate mesoderm (P).

Expression Data

Genes:	lft1 lft2
Fish:	WT
Anatomical Terms:	blastodisc epithalamus left side forerunner cell group hypoblast dorsal region Kupffer's vesicle lateral plate mesoderm left side margin margin dorsal side notochord anterior region notochord posterior region polster prechordal plate presumptive floor plate
Stage Range:	Dome to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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