FIGURE

Fig. 5

ID

ZDB-FIG-140314-16

Publication

Bisgrove et al., 1999 - Regulation of midline development by antagonism of lefty and nodal signaling

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Fig. 5

Ectopic expression of Lefty1, Lefty2 or Cyclops affects the endogenous expression of each other. (A-C) cyc expression at 85% epiboly. In uninjected embryos cyc is expressed in the midline (A). Expression is abolished in embryos injected with 25 pg of RNA encoding either Lft1-MT (B) or Lft2-MT (C). (D-F) lft2 expression at 85% epiboly. In control embryos lft2 is expressed in the midline (D). Expression of lft2 is abolished in embryos injected with 25 pg of RNA encoding Lft1-MT (E) and is expanded in embryos injected with 10 pg of cyc RNA (F). Embryos (dorsal views) were processed by in situ hybridization followed by anti-myc immunohistochemistry to identify clones of cells expressing Lft1-MT or Lft2-MT.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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