FIGURE

Fig. 5

ID

ZDB-FIG-140304-40

Publication

Gariano et al., 2014 - Analysis of three mu-AP1 subunits during zebrafish development

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Morphological defects in ap1m1MO and ap1m3MO single morphants. Embryos were injected at the two-cell stage and examined at 24 and 48 hpf. A: Lateral view and dorsal view at 24 hpf. Single morphants of ap1m1 and ap1m3 exhibit brain malformations (d,e,g,h) with unclear boundaries between brain subdivisions, especially at hindbrain and midbrain region (f,i). ap1m3MO morphants showed poorly defined somites (g). B: At 48 hpf, CNS abnormalities became more pronounced. The forebrain ventricle in both single morphants (c,e; control in a). Dorsal view of ap1m1MO and ap1m3MO embryos revealed a severe disorganization of CNS structures (d,f). a,c,e: lateral view anterior to the left. b,d,f: dorsal view. h, hindbrain; c, cerebellum; teg, tegmentum; dd, dorsal diencephalon; mhb, midbrain–hindbrain boundary; m, midbrain; fv, forebrain ventricle.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-ap1m1 AB + MO1-ap1m3
Knockdown Reagents:	MO1-ap1m1 MO1-ap1m3
Observed In:	brain central nervous system cerebellum forebrain ventricle hatching hindbrain midbrain midbrain hindbrain boundary pericardium somite border
Stage Range:	Prim-5 to Long-pec

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dev. Dyn.