Fig. 4
- ID
- ZDB-FIG-140122-28
- Publication
- Venkiteswaran et al., 2013 - Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue
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Cxcr7 Generates the Sdf1-Signaling Gradient across the Primordium (A) Single confocal slices through the primordium in live 36 hpf embryos of the indicated genotypes, all carrying the Sdf1-signaling sensor. The FmemRed/FmemGreen images are inverted heat maps of the ratio. (B) Mean FmemRed/FmemGreen along the anterior-posterior axis of n e 10 primordia with 0 μm representing the front of each primordium. Red circles indicate the mean FmemRed/FmemGreen in embryos of the indicated genotype; black circles, where present, indicate the mean FmemRed/FmemGreen of wild-type embryos, heat-shocked control embryos, or cxcr7-deficient control embryos. Gray bars indicate SEM. Anterior is to the left, and dorsal is up in (A). Scale bar, 20 μm. Note that cxcr7-deficient; tg(tubb2b:cxcr7b) embryos were injected with a low dose of cxcr7a MO mix. |
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| Stage: | Prim-25 |
Reprinted from Cell, 155(3), Venkiteswaran, G., Lewellis, S.W., Wang, J., Reynolds, E., Nicholson, C., and Knaut, H., Generation and Dynamics of an Endogenous, Self-Generated Signaling Gradient across a Migrating Tissue, 674-687, Copyright (2013) with permission from Elsevier. Full text @ Cell