FIGURE

Fig. 3

ID

ZDB-FIG-140114-30

Publication

Wilkins et al., 2013 - p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis

Other Figures

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Fig. 3

Liver histology and ultrastructure in Cirhin-deficient larvae.

(A-F) Liver histology of wild-type (A-C) and Cirhin-deficient (D-F) larvae is indistinguishable, although liver size and yolk consumption are decreased in Cirhin-deficient larvae as a result of mild developmental delay (D-E). Insets in B-C, E-F are high-magnification views of associated panel. (G-L) Transmission electron microscopy of wild-type (G-I) and Cirhin-deficient (J-L) larvae. Compared to wild-type, Cirhin-deficient hepatocytes have increased rough endoplasmic reticulum (J, red asterisk) and occasional cytoplasmic lamellations consistent with bile (K-L, black arrowheads). Biliary cells are outlined by red dashed lines and appear normal (H,K).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-utp4 WT + MO2-utp4
Knockdown Reagents:	MO1-utp4 MO2-utp4
Observed In:	hepatocyte rough endoplasmic reticulum intrahepatic bile duct epithelial cell liver yolk
Stage:	Day 5

Phenotype Detail

Acknowledgments

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