FIGURE

Fig. 5

ID

ZDB-FIG-130906-27

Publication

Sorrell et al., 2013 - Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish

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Fig. 5

Depletion of Tcf7l1 proteins is epistatic to inhibition of Wnt signaling prior to gastrulation. Expression of myl7 in (A) control uninjected, (B) Dkk+/uninjected, (C) Tcf7l1 deficient, and (D) Dkk+/Tcf7l1 deficient embryos at the 20s stage. (E) Measurements of the area of myl7 expression cells and the fold difference in the area measurements. For analysis of myl7 expression areas, control n=29, Dkk+/uninjected n=21, Tcf7l1 deficient n=36, and Dkk+/Tcf7l1 deficient n=30. Images are from flatmounted embryos. Views are dorsal with anterior up. Double asterisks indicate statistically significant difference from control uninjected and Dkk+/uninjected embryos, but not different from each other.

Expression Data

Gene:	myl7
Fish:	w32Tg w32Tg + MO1-tcf7l1a + MO1-tcf7l1b + MO4-tp53
Condition:	heat shock
Knockdown Reagents:	MO1-tcf7l1a MO1-tcf7l1b MO4-tp53
Anatomical Term:	heart rudiment
Stage:	20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 380(2), Sorrell, M.R., Dohn, T.E., D'Aniello, E., and Waxman, J.S., Tcf7l1 proteins cell autonomously restrict cardiomyocyte and promote endothelial specification in zebrafish, 199-210, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.