FIGURE

Fig. 3

ID

ZDB-FIG-130726-48

Publication

Mahmood et al., 2013 - Generation and validation of a zebrafish model of EAST (Epilepsy, ataxia, sensorineural deafness and tubulopathy) syndrome

Other Figures

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Fig. 3

kcnj10a morphant ZF display movement defects. (A) Morphants showed an increased frequency of spontaneous contractions at 30 hpf, and this increase could be rescued by co-injection of normal human KCNJ10 cRNA, but not R65P mutant cRNA (n=10-15 per experimental condition). (B) At 120 hpf, we observed abnormal movements with a significantly higher frequency of jaw, eye and fin movements in kcnj10a morphants (black bars, n=7) than in controls (white bars, n=5). (C,D) Shown are 3-minute tracks from four WT (C) and four kcnj10a morphant (D) ZF at 120 hpf after being startled by touch. kcnj10a morphants (D) exhibit circling locomotion with frequent ′loops′ around their vertical axis. *P<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO1-kcnj10a
Knockdown Reagent:	MO1-kcnj10a
Observed In:	eye locomotory behavior mandibular arch skeleton thigmotaxis whole organism
Stage Range:	Prim-15 to Day 5

Phenotype Detail

Acknowledgments

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