FIGURE

Fig. 5

ID

ZDB-FIG-130726-31

Publication

Head et al., 2013 - Activation of canonical Wnt/beta-catenin signaling stimulates proliferation in neuromasts in the zebrafish posterior lateral line

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Fig. 5

Azakenpaullone triggers an increase in the number of hair cells differentiating in developing lateral line neuromasts. (A-B) Fish treated with 1-azakenapaullone beginning at 48 hpf show a dramatic increase in the size of the neuromast and in the number of HCS-1 positive hair cells at 7 dpf compared to DMSO-treated controls. (C) Quantification of the number of HCS-1 positive hair cells in an anterior neuromast from 7 fish treated with Az or DMSO beginning at 48 hpf. At both 4 dpf and 7 dpf, Az stimulated a significant increase in the number of differentiated hair cells, with more than twice as many hair cells produced by 7 dpf (*P < 0.01). (D-E) The increase in hair cell number can also be seen using the Brn3c:GFP transgenic line that express GFP in all of their hair cells. In all images, the dashed line represents the extent of the neuromast. Scale bar: 10 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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