Fig. 4

Morpholino-mediated knockdown of p53 does fail to rescue defective expansion of ptf1a-expressing pancreas progenitor cells in rpl mutant embryos. (A) Injection of embryos produced by rpl23a^{hi2582/ +} ;ptf1a:eGFP^jh1;ins:mCherry^jh2 incross with 1 ng p53ATG MO does not rescue hypoplastic pancreatic phenotype. (B) Incidence of abnormal pancreas development among embryos produced by rpl23a^{hi2582/ +} ;ptf1a:eGFP^jh1;ins:mCherry ^jh2 incross injected with either p53ATG MO or mock control (phenotypic, red; wild type, blue). (C) Injection of embryos produced by rpl6^{hi3655b/ +} ;ptf1a:eGFP^jh1;ins:mCherry^jh2 incross with 1 ng p53ATG MO does not rescue hypoplastic pancreatic phenotype. (D) Incidence of abnormal pancreas development among embryos produced by rpl6^{hi3655b/ +} ;ptf1a:eGFP^jh1;ins:mCherry ^jh2 incross injected with either p53ATG MO or mock control (phenotypic, red; wild type, blue). Color images available online at www.liebertpub.com/zeb