FIGURE

Fig. 2

ID

ZDB-FIG-130128-42

Publication

Garnaas et al., 2012 - Rargb regulates organ laterality in a zebrafish model of right atrial isomerism

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Fig. 2

Raldhs 2 and 4 temporally regulate liver development. (A?I) Wild type embryos were injected with raldh2 or raldh4 MO at the 1-cell stage, and liver development was assessed over the next 72 h. In situ hybridization for the hepatoblast marker prox1 at 30 hpf (A?C) and 48 hpf (D?F) and hepatocyte marker lfabp at 72 hpf (G?I) demonstrates distinct temporal requirements for Raldh2 and Raldh4 during liver development. Arrowheads denote the liver primordium, and the dotted lines outline the liver. Scale bars: 100 µm.

Expression Data

Genes:	fabp10a prox1a
Fish:	WT WT + MO2-aldh8a1 WT + MO3-aldh1a2
Knockdown Reagents:	MO2-aldh8a1 MO3-aldh1a2
Anatomical Term:	liver
Stage Range:	Prim-15 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-aldh8a1 WT + MO3-aldh1a2
Knockdown Reagents:	MO2-aldh8a1 MO3-aldh1a2
Observed In:	liver
Stage Range:	Prim-15 to Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 372(2), Garnaas, M.K., Cutting, C.C., Meyers, A., Kelsey, P.B., Harris, J.M., North, T.E., and Goessling, W., Rargb regulates organ laterality in a zebrafish model of right atrial isomerism, 178-189, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.