FIGURE

Fig. 7

ID

ZDB-FIG-130110-27

Publication

Dalcq et al., 2012 - RUNX3, EGR1 and SOX9B Form a Regulatory Cascade Required to Modulate BMP-Signaling during Cranial Cartilage Development in Zebrafish

Other Figures

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Fig. 7

Expression of fsta is increased in runx3 and egr1 morphants and sox9b mutants.

Lateral views of in situ hybridizations, anterior to the left. Scale bars 100 μm. (A-F) Compared to controls or wild-type embryos, expression of fsta is up-regulated in egr1 morphants (A,B), runx3 morphants (C,D), and homozygous sox9b mutants (E,F) at 48 hpf. pharyngeal endoderm (pe). (G,H) 4 dpf Alcian Blue stained larvae injected with MOcon 6 ng (K) and MOfsta 6ng (L). Knock-down of fsta causes a hyperplasia of the viscerocranium. Meckel?s cartilage (m), ceratohyal (ch), ceratobranchials 1 to 5 (cb1-5).

Expression Data

Gene:	fsta
Fish:	WT WT + MO1-runx3 WT + MO3-egr1 Df(Chr03:sox8b,sox9b)b971/b971
Knockdown Reagents:	MO1-runx3 MO3-egr1
Anatomical Terms:	brain pharyngeal pouch
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-fsta
Knockdown Reagent:	MO1-fsta
Observed In:	ceratobranchial cartilage splanchnocranium
Stage:	Day 4

Phenotype Detail

Acknowledgments

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