FIGURE

Fig. 4

ID

ZDB-FIG-121210-24

Publication

Shin et al., 2012 - Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

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Fig. 4

nf1a^-/-; nf1b^-/- larvae exhibit myelination defects. (A–D) plp1a expression is decreased in glial cells of the midbrain and hindbrain regions (A,B, boxes) as well as the dorsal (black bracket) and ventral (white brackets) spinal cord of nf1a^-/-; nf1b^-/- larvae (B,D) as compared to wild-type larvae (A,C) by whole-mount in situ hybridization at 5 dpf. (E,F) mbp expression is elevated in Schwann cells of the PLLn (arrowheads) of nf1a^-/-; nf1b^-/- larvae (F) as compared to wild-type larvae (E) by whole-mount in situ hybridization at 5 dpf. (G-J) Transverse sections through the ventral spinal cord nf1a^-/-; nf1b^-/-larvae (H, boxed region magnified in J) demonstrate defects in formation of compact myelin sheaths as compared with wild-type larvae (G, boxed region magnified in I) at 8 dpf. Scale bars: 100 μm (A-F) and 0.5 μm (G-J).

Expression Data

Genes:	mbpa plp1a
Fish:	WT nf1a^p301/p301; nf1b^p303/p303
Anatomical Terms:	hindbrain glial cell (sensu Vertebrata) midbrain glial cell (sensu Vertebrata) posterior lateral line myelinating Schwann cell spinal cord glial cell (sensu Vertebrata)
Stage:	Day 5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	nf1a^p301/p301; nf1b^p303/p303
Observed In:	central nervous system oligodendrocyte central nervous system myelination oligodendrocyte differentiation posterior lateral line immature Schwann cell Schwann cell differentiation spinal cord myelin sheath
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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