FIGURE

Fig. 1

ID

ZDB-FIG-121101-10

Publication

Weiss et al., 2012 - Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos

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Fig. 1

lmo2 mutant zebrafish embryos. (A and B) Heads of normal (A) and lmo2 mutant (B) live embryos at 2 dpf. Arrows point at the optic fissure. (C and D) 30 h post-fertilization (hpf) normal (C) and lmo2 mutant (D) embryos labeled for RBC marker gata1. (E and E′) Chromatograms showing normal lmo2 (E) and mutant lmo2^vu270 (E′) coding sequence at the mutation site. (F) Schematic presentation of Lmo2 protein and the site of predicted truncation in Lmo2 encoded by vu270 allele (arrow). (G) Quantification of rescue of lmo2 mutant phenotypes by injection of RNA encoding normal Lmo2 or Lmo2^C94X. Numbers are summary of at least two independent experiments. (***p<0.0001).

Expression Data

Gene:	gata1a
Fish:	WT lmo2^vu270/vu270 (AB)
Anatomical Term:	nucleate erythrocyte
Stage:	Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lmo2^vu270/vu270 (AB)
Observed In:	embryonic hemopoiesis embryonic retina morphogenesis in camera-type eye head nucleate erythrocyte optic fissure whole organism
Stage Range:	Prim-15 to Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 369(2), Weiss, O., Kaufman, R., Michaeli, N., and Inbal, A., Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos, 191-198, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.