FIGURE

Fig. 2

ID

ZDB-FIG-121101-11

Publication

Weiss et al., 2012 - Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos

Other Figures

All Figure Page

Back to All Figure Page

Fig. 2

Edema and ocular vessel phenotypes in lmo2 mutant embryos. (A and B) Transverse sections of heads from normal (A) and lmo2 mutant (B) embryos at 2.5 dpf. In the mutant note enlarged ventricle and white spaces within head and eye (arrow) tissues suggesting severe edema. Asterisks mark brain ventricle. (C and D) Three-dimensional shadow rendering confocal images of 55–56 hpf Tg(kdrl:EGFP) normal (C) and lmo2 mutant (D) eyes in frontal view. (E and F) Three-dimensional maximum projection confocal images of 55–56 hpf Tg(kdrl:EGFP) normal (E) and lmo2 mutant (F) eyes in lateral view. Arrows point at different regions of the superficial ring vessel. (G and H) FITC-dextran microangiography of Tg(kdrl:HsHRAS-mCherry) normal (G) and lmo2 mutant (H) eyes in live embryos at 1.5 dpf, lateral view. Note accumulation of dye around the mutant eye (arrowheads). drv, dorsal radial vessel; ha, hyaloid artery; hc, hyaloid capillaries; hv, hyaloid vein; nrv, nasal radial vessel; vrv, ventral radial vessel. In (E–H) anterior is to the left.

Expression Data

Genes:	EGFP mCherry
Fish:	s843Tg s896Tg lmo2^vu270/vu270; s843Tg lmo2^vu270/vu270; s896Tg
Anatomical Term:	ocular blood vessel blood vessel endothelium
Stage Range:	Prim-25 to Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lmo2^vu270/vu270 (AB) lmo2^vu270/vu270; s843Tg lmo2^vu270/vu270; s896Tg
Observed In:	eye head hyaloid artery hyaloid vein ocular blood vessel retinal blood vessel morphogenesis ventricular system
Stage Range:	Prim-25 to Pec-fin

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 369(2), Weiss, O., Kaufman, R., Michaeli, N., and Inbal, A., Abnormal vasculature interferes with optic fissure closure in lmo2 mutant zebrafish embryos, 191-198, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.