FIGURE

Fig. 5

ID

ZDB-FIG-121026-14

Publication

Hsu et al., 2012 - Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm

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Fig. 5

p120 catenin δ1 depletion by δ1 splice-MO causes severe defects in somite formation in later stages of development including defects in yolk extension, tail extension, and eye formation. Embryos were imaged with Nomarski optics. A: Images of side views of live zebrafish embryos, anterior left, at the 14-somite stage (16 hpf). Embryos were uninjected or injected as indicated in the panels with δ1 splice-MO (Sp-MO) and/or Xenopus p120 catenin δ1 mRNA (Xp120 mRNA). Ventral arrows indicate the positions of the head and tailbud. Scale bars = 250 μm. B: Embryos were injected with 6 pg δ1 splice-MO (Sp-MO). C: Comparisons of side views of embryos that were uninjected or injected with δ1 splice-MO and/or Xp120 catenin δ1 mRNA at the 1-cell stage, and then imaged at the Prim 15 stage (30 hpf, anterior top). Eighty-six percent of the embryos injected with Sp-MO survived to Prim 15. Scale bars = 160 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO3-ctnnd1
Knockdown Reagent:	MO3-ctnnd1
Observed In:	brain development extension eye development post-vent region somitogenesis whole organism whole organism anatomical axis
Stage Range:	14-19 somites to Prim-15

Phenotype Detail

Acknowledgments

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