FIGURE

Fig. 8

ID

ZDB-FIG-120829-1

Publication

Takada et al., 2011 - swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation

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Fig. 8

Swap70 loss-of-function does not affect OPC morphology and differentiation. Images of migrating OPCs (A, B) and wrapping oligodendrocytes (C, D) in living 3 dpf larvae visualized using a Tg(nkx2.2a:mEGFP) transgenic reporter. Membrane processes of OPCs and myelinating oligodendrocytes appear normal in MO^swap70-sp-injected larvae. (E, F) plp1a mRNA expression at 3 dpf. (G, H) mbp mRNA expression at 3 dpf. Both plp1a and mbp appear to be expressed at normal levels in MO^swap70-sp-injected larvae, although the number of cells expressing these genes in MO-injected larvae is fewer than in wild type.

Expression Data

Genes:	EGFP mbpa plp1a
Fish:	vu17Tg vu17Tg + MO3-swap70b
Knockdown Reagent:	MO3-swap70b
Anatomical Term:	oligodendrocyte
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vu17Tg + MO3-swap70b
Knockdown Reagent:	MO3-swap70b
Observed In:	oligodendrocyte
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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Reprinted from Molecular and cellular neurosciences, 48(3), Takada, N., and Appel, B., swap70 Promotes neural precursor cell cycle exit and oligodendrocyte formation, 225-35, Copyright (2011) with permission from Elsevier. Full text @ Mol. Cell Neurosci.