FIGURE

Fig. 1

ID

ZDB-FIG-120815-28

Publication

Liu et al., 2012 - betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8

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Fig. 1

Mutation of Git1 binding residues in βPix or knockdown of Git1 leads to hemorrhage. A) Expression of mutant βPix lacking residues important for Git1 binding (βPix IP/EG) leads to increased hemorrhage in wild type vessels, and in bbh^m292 mutants. B) Knockdown of Git1 by either a Git1^i1e2 or Git1^ATG morpholino leads to increased hemorrhage as compared to wild type embryos. C) Wild type embryo at 48 hpf. D) Git1^i1e2 morphant shows hemorrhage (arrow) and hydrocephalus (star).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	arhgef7b^m292/m292 TL + MO1-git1 TL + MO2-git1
Knockdown Reagents:	MO1-git1 MO2-git1
Observed In:	brain brain vasculature
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 363(1), Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J., betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8, 95-105, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.