FIGURE

Fig. S3

ID

ZDB-FIG-120815-19

Publication

Liu et al., 2012 - betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8

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Fig. S3

Morpholino efficiency test and hemorrhage phenotype for integrin morphants.

(A) itgav^MOf and itgav^MOr primers were used to amplify integrin α v around the exonintron boundary targeted by the itgav^e3i3 MO. Black arrows denote the wildtype band. Stars denote misspliced new products seen only in the morphants. (B) Hemorrhages (arrow) are observed in the head of itgav^ATG morphants between 50 – 52 hpf. (C) itgb8^MOf and itgb8^MOr primers were used to amplify integrin β 8 around the exonintron boundary targeted by both itgb8^e2i2 and itgb8e²ⁱ¹ morpholinos. Black arrows denote the wildtype band, while a star denotes misspliced new products seen only in the morphants. (D) Hemorrhages (arrow) are observed in the head of itgb8^e2i1 morphants.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO2-itgb8 TL + MO5-itgav
Knockdown Reagents:	MO2-itgb8 MO5-itgav
Observed In:	brain brain vasculature
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 363(1), Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J., betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8, 95-105, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.