ZFIN ID: ZDB-FIG-120627-32
Activation of an apoptotic program in the thyroid primordium of bcl2l, pax2a or nk2.1a morphant embryos. Thyroid and apoptotic cells are stained with hhex riboprobe and active-caspase-3 antibody. Lateral (A) and (B) and ventral views (C) and (D) with anterior to the left, and cross sections (E) and (F) with anterior to the top, of 40 hpf embryos. Experimental morpholino is indicated bottom right, stage bottom left and markers on the left. (A) and (B) Embryos injected with control MO (A) or with bcl2l MO (B). (C) and (D) Embryos injected with control MO (C) or pax2a MO (D) deprived of yolk and flattened on their ventral side. (C′), (D′) Magnification of thyroid primordium in (C) and (D). (E) and (F) Embryos injected with control MO (E) or nk21a MO (F). Arrow indicates active-caspase-3 positive cells in the thyroid primordium.
Antibody Labeling Details No data available
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Reprinted from Developmental Biology, 366(2), Porreca, I., De Felice, E., Fagman, H., Di Lauro, R., and Sordino, P., Zebrafish bcl2l is a survival factor in thyroid development, 142-152, Copyright
(2012) with permission from Elsevier.
Full text @ Dev. Biol.