FIGURE

Fig. 5

ID

ZDB-FIG-120627-29

Publication

Porreca et al., 2012 - Zebrafish bcl2l is a survival factor in thyroid development

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Fig. 5

Morphology of bcl2l morphant embryos. Lateral views with anterior to the left of 24 hpf embryos. Experimental morpholino is indicated at bottom right, percentage (indicating the fraction of the described phenotype) at bottom left. (A) General morphology of control MO-injected embryo. (B)–(D) bcl2l MO injected embryos showing a broad region of opacity due to cell death in the head (arrow in (B)), hypoplastic central nervous system (arrow in (C)) and lack of yolk extension (arrow in (D)). (E)–(G) immunostaining at 24 hpf of active-caspase-3 in control MO (E), bcl2l MO (F) injected embryos and embryos co-injected with bcl2l MO and bcl2l mRNA (G). The strong activation of caspase-3 in bcl2l downregulated embryos is fully counteracted by co-injection of bcl2l mRNA. (E′), (F′), (G′) Magnifications of active caspase-3 positive cells in (E), (F) and (G).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-bcl2l1
Knockdown Reagent:	MO1-bcl2l1
Observed In:	apoptotic process central nervous system extension whole organism
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 366(2), Porreca, I., De Felice, E., Fagman, H., Di Lauro, R., and Sordino, P., Zebrafish bcl2l is a survival factor in thyroid development, 142-152, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.