FIGURE

Fig. 8

ID

ZDB-FIG-120517-8

Publication

Gongal et al., 2011 - Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning

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Fig. 8

Retinoic acid regulates gli3 transcription and rescues gli3 levels in hmx4 morphants. Treatment with RA induces gli3 expression throughout the forebrain (A–B) of 18 hpf embryos, while inhibiting RA synthesis with DEAB causes its reduction (C–D). (E–H) hmx4 morphants have reduced gli3 expression, which is significantly rescued by RA treatment (see text for frequencies and statistical tests).

Expression Data

Gene:	gli3
Fish:	AB AB + MO1-hmx4 + MO2-hmx4 + MO4-tp53
Condition:	chemical treatment: all-trans-retinoic acid
Knockdown Reagents:	MO1-hmx4 MO2-hmx4 MO4-tp53
Anatomical Term:	brain
Stage:	14-19 somites

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.