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Fig. 8
Retinoic acid regulates gli3 transcription and rescues gli3 levels in hmx4 morphants. Treatment with RA induces gli3 expression throughout the forebrain (A–B) of 18 hpf embryos, while inhibiting RA synthesis with DEAB causes its reduction (C–D). (E–H) hmx4 morphants have reduced gli3 expression, which is significantly rescued by RA treatment (see text for frequencies and statistical tests).
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Reprinted from Developmental Biology, 355(1), Gongal, P.A., March, L.D., Holly, V.L., Pillay, L.M., Berry-Wynne, K.M., Kagechika, H., and Waskiewicz, A.J., Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning, 55-64, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.