FIGURE
Fig. 5
- ID
- ZDB-FIG-111215-20
- Publication
- Nguyen et al., 2011 - A high level of liver-specific expression of oncogenic KrasV12 drives robust liver tumorigenesis in transgenic zebrafish
- Other Figures
- All Figure Page
- Back to All Figure Page
Fig. 5
Activation of the Wnt–β-catenin pathway during krasV12 liver tumorigenesis. Representative immunohistochemical liver sections from WT zebrafish as the control and krasV12 transgenic fish with liver hyperplasia and carcinoma are shown. (A) Immunohistochemistry for β-catenin showing an increasing nuclear localization of β-catenin during HCC progression. (B) Immunohistochemistry for E-cadherin showing loss of membranous E-cadherin expression during tumor growth. (C) Immunohistochemistry for Ki67 showing a high expression level of Ki67 in cell nuclei, which increased from hyperplasia to carcinoma. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
| Fish: | |
|---|---|
| Observed In: | |
| Stage: | Adult |
Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and
ZFIN has permission only to display this image to its users.
Additional permissions should be obtained from the applicable author or publisher of the image.
Full text @ Dis. Model. Mech.