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Fig. 5

ID: ZDB-IMAGE-111215-21
Publication: Nguyen et al., 2011 - A high level of liver-specific expression of oncogenic Kras^V12 drives robust liver tumorigenesis in transgenic zebrafish
All Figures: Figures for Nguyen et al., 2011

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Fig. 5 Activation of the Wnt–β-catenin pathway during kras^V12 liver tumorigenesis. Representative immunohistochemical liver sections from WT zebrafish as the control and kras^V12 transgenic fish with liver hyperplasia and carcinoma are shown. (A) Immunohistochemistry for β-catenin showing an increasing nuclear localization of β-catenin during HCC progression. (B) Immunohistochemistry for E-cadherin showing loss of membranous E-cadherin expression during tumor growth. (C) Immunohistochemistry for Ki67 showing a high expression level of Ki67 in cell nuclei, which increased from hyperplasia to carcinoma.

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