FIGURE

Fig. 11

ID

ZDB-FIG-111019-12

Publication

Cox et al., 2011 - Diverse mechanisms for assembly of branchiomeric nerves

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Fig. 11

foxd3 nulls have lost peripheral glia, resulting in some cranial afferents becoming defasciculated and misrouted. A: 4 dpf control foxd3^{+/ -}sox:rfp larva, B: 4 dpf mutant foxd3^{- / -};sox:rfp larva showing loss of the Xth sheath and gPLL satellite glia. C: 4 dpf control foxd3^{+/ -};isl:gfp larva, D: 4 dpf mutant foxd3^{- / -};isl:gfp larva showing correct proximal eV, eVII and eX projections. E: 4 dpf control foxd3^{+/ -}3.2:gfp larva, F–H: 4 dpf mutant foxd3^{- / -}3.2:gfp larvae show a spectrum of axon misrouting; subsets of aVII (G), aIX (G,H) and aX (F–H) afferent axons are defasciculated and misrouted (e.g., arrows in F), whereas the remaining axons project correctly. gPLL, posterior lateral line ganglion satellite cells; ov, otic vesicle; eV, efferent nerve of bmnV; eVII, efferent nerve of bmnVII; eX, efferent nerve of bmnX; aV, afferent nerve of gV; aVII, afferent nerve of gVII; aIX, afferent nerve of gIX; aX, afferent nerve of gX; llf, lateral longitudinal fascicle. Anterior to left, dorsal at top. All scale bars are 100 μm.

Expression Data

Genes:	EGFP GFP mRFP
Fish:	rw0Tg sl1Tg vu234Tg foxd3^zdf10/zdf10; rw0Tg foxd3^zdf10/zdf10; sl1Tg foxd3^zdf10/zdf10; vu234Tg
Anatomical Terms:	cranial nerve V efferent neuron cranial nerve VII afferent neuron cranial nerve X efferent neuron facial ganglion afferent neuron glossopharyngeal ganglion afferent neuron posterior lateral line ganglion glial cell trigeminal ganglion afferent neuron vagal ganglion afferent neuron vagal ganglion glial cell
Stage:	Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	foxd3^zdf10/zdf10; sl1Tg foxd3^zdf10/zdf10; vu234Tg
Observed In:	cranial nerve X glial cell facial ganglion axon facial ganglion sensory neuron axon guidance glossopharyngeal ganglion axon glossopharyngeal ganglion sensory neuron axon guidance posterior lateral line ganglion glial cell vagal ganglion axon vagal ganglion glial cell vagal ganglion sensory neuron axon guidance
Stage:	Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 357(2), Cox, J.A., Lamora, A., Johnson, S.L., and Voigt, M.M., Diverse mechanisms for assembly of branchiomeric nerves, 305-17, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.