FIGURE

Fig. S7

ID

ZDB-FIG-111014-25

Publication

Hammond et al., 2011 - Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle

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Fig. S7

Expression of rhombomere-specific markers in the hindbrain of heat-shocked hsp70:fgf3, SU5402-treated wild-type and SU5402-treated smo^-/- embryos. (A,B,E,F,I,J) 21S wild-type embryos treated with 10 μM SU5402/0.5% DMSO and control embryos treated with DMSO from 10 to 20S. (C,D,G,H,K,L) 21S hsp70:fgf3 transgenic (tg) and sibling (sib) embryos heat-shocked at 10S. (A-D) egr2b (krox20) expression, found in r3 and r5 in wild-type embryos, is normal in SU5402-treated embryos, but extends at a low level into r6 in hsp70:fgf3 transgenic embryos. (E-H) hoxb1 is expressed as normal in r4 of all embryos, although r4 appears reduced in hsp70:fgf3 transgenics. (I-L) val (mafba) expression, detected in r5 and r6 in wild-type embryos, is normal in SU5402-treated embryos but extends slightly into r6 in hsp70:fgf3 transgenic embryos. (M-X) 10 μM SU5402/0.5% DMSO-treated and control DMSO-treated smo^-/- and sibling embryos at 24S, treated from 10 to 20S. Domains of egr2b (krox20), hoxb1 and val (mafba) expression are normal in smo^-/-, SU5402-treated sibling and SU5402-treated smo^-/- embryos. Dorsal views; anterior to left. Scale bars: 50 μm for all panels.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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