Fig. 3
- ID
- ZDB-FIG-110920-54
- Publication
- Bohnsack et al., 2011 - Phenothiourea Sensitizes Zebrafish Cranial Neural Crest and Extraocular Muscle Development to Changes in Retinoic Acid and IGF Signaling
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PTU alters IGF regulation of craniofacial muscle development. 72 hpf Tg(α-actin::EGFP) embryos that were injected with morpholinos against igf1ra (A?D), igf1rb (E?H), or control (globin; I?L) and were raised in control media (A, B, E, F, I, J) or with 0.003% PTU at 12 hpf (C, D, G, H, K, L). Morpholino knockdown of igf1ra or igf1rb in the roy background (in the absence of PTU; A, B, E, F) did not disrupt craniofacial development as compared to control (I, J). Morpholino knockdown of igf1ra in the presence of 0.003% PTU caused developmental delay only in the presence of 0.003% PTU (C, D compared to K, L). Knockdown of igf1rb inhibited jaw formation and caused mild thickening of extraocular muscles in the presence of 0.003% PTU (G, H), but not in control media (E, F). IR, inferior rectus; IO, inferior oblique; AM, anterior mandibulae. |