FIGURE

Fig. 5

ID

ZDB-FIG-110909-81

Publication

Chang et al., 2011 - liver-enriched gene 1a and 1b Encode Novel Secretory Proteins Essential for Normal Liver Development in Zebrafish

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Fig. 5

Both Leg1a and Leg1b are essential for normal liver development.

(A) leg1-MO^ATG (ATG-MO), leg1a-MO (1a-MO) and leg1b-MO (1b-MO) all resulted in small liver phenotype but with different severity. (B) Statistical analysis of liver size in leg1-MO^ATG (ATG-MO), leg1a-MO (1a-MO) or leg1b-MO (1b-MO) morphants based on WISH signal intensity of fabp10a. Signal intensity (Y-axis) was plotted against body length (X-axis). 20–23 embryos were used for statistical analysis in each case. (C) WISH using fabp10a probe to examine rescue of the small liver phenotype caused by leg1-MO^ATG with leg1a (1a mRNA), leg1b (1b mRNA) mRNA, or combination of leg1a and leg1b mRNA (1a+1b mRNA). (D) Statistical analysis of liver size in each individual leg1-MO^ATG morphant based on WISH signal intensity of fabp10a. 19–23 embryos were used for statistical analysis in each case except for WT (14 embryos were used).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-leg1.2 AB + MO3-leg1.1 AB + MO1-leg1.1,leg1.2
Knockdown Reagents:	MO1-leg1.1,leg1.2 MO1-leg1.2 MO3-leg1.1
Observed In:	liver
Stage:	Day 4

Phenotype Detail

Acknowledgments

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