FIGURE

Fig. 7

ID

ZDB-FIG-110909-26

Publication

Lewis et al., 2011 - Celsr3 Is Required for Normal Development of GABA Circuits in the Inner Retina

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Fig. 7

The number of GABA receptor puncta is increased on celsr3 mutant ON-bipolar terminals.

A) ON-bipolar cells in cryosection were stained with anti-PKC antibodies and anti-GABAγ2. The PKC label fields were overlayed on the GABA signal, and the number of puncta was counted in each terminal rotated and visualized in 3D. Image shows merged z-stacks. Scale bars are 5 μm. B) The GABA puncta in the ON-bipolar terminals per μm³ for WT and celsr3 mutants (n = 60 terminals for each). Error bars are standard error. C) Mosaic 2 dpf larva containing WT cells in the eye (yellow dashed line) of a celsr3 mutant animal. Despite a large WT eye field transplant, this animal remained OKR negative. The tan dashed line outlines larva body.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	celsr3^w65/w65 (AB)
Observed In:	ON-bipolar cell axon terminus
Stage:	Day 6

Phenotype Detail

Acknowledgments

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