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Fig. s8

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ZDB-FIG-110622-38

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Waxman et al., 2011 - Zebrafish retinoic acid receptors function as context-dependent transcriptional activators

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Fig. s8

Chimeric human/zebrafish dominant negative RARs can inhibit expression of RA-responsive target genes. (A?D) Uninjected control embryos. (E?H) Embryos injected with mRNA encoding a hs-dr RAR fusion protein, in which the human A?C domains are fused to the zebrafish D?ΔF domains. (I?L) Embryos injected with mRNA encoding a dr-hs RAR fusion protein, in which the zebrafish A?C domains are fused to the human D?ΔF domains. Although neither chimeric protein was as effective as the human dnRARa (Figs. 8O?R), either can inhibit expression of RA-responsive genes.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 352(1), Waxman, J.S., and Yelon, D., Zebrafish retinoic acid receptors function as context-dependent transcriptional activators, 128-140, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.