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Fig. s8
Chimeric human/zebrafish dominant negative RARs can inhibit expression of RA-responsive target genes. (A–D) Uninjected control embryos. (E–H) Embryos injected with mRNA encoding a hs-dr RAR fusion protein, in which the human A–C domains are fused to the zebrafish D–ΔF domains. (I–L) Embryos injected with mRNA encoding a dr-hs RAR fusion protein, in which the zebrafish A–C domains are fused to the human D–ΔF domains. Although neither chimeric protein was as effective as the human dnRARa (Figs. 8O–R), either can inhibit expression of RA-responsive genes.
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Reprinted from Developmental Biology, 352(1), Waxman, J.S., and Yelon, D., Zebrafish retinoic acid receptors function as context-dependent transcriptional activators, 128-140, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.