Fig. 3

Developmental expression of mab21l1 and mab21l2. At <11 hpf, mab21l2 and mab21l1 are expressed in optic vesicles and tectum (A,B, A2,B2). At <24 hpf, mab21l2, but not mab21l1, is expressed in the lens (C,C2), and only mab21l1 is expressed in olfactory bulbs (D,E, D2,E2). mab21l1 is detected throughout the retina (C2), mab21l2 is confined to the inner retina (C, dots: retina) and both are expressed in tectum and hindbrain (D, D2). At <3 dpf, mab21l1 is expressed in ganglion and amacrine cells (F2), retinal mab21l2 is confined to cells proximal to the lens (F). In the tectum, mab21l1 is widely expressed (G2,H2), whereas only the posterior region expresses mab21l2 (G,H). In the hindbrain, mab21l1 is strongly expressed in the anterior region (G2,H2); mab21l2 is expressed throughout (G2,H2). In branchial arches, mab21l2 is expressed along all craniofacial processes (H); mab21l1 is confined to regions close to the otic vesicle (H2). At 5 dpf, mab21l1 remains expressed in amacrine and ganglion cells, but is downregulated in a ventral patch where mab21l2 is confined (I,I2). mab21l2 expression appears unchanged in the brain but reduced in branchial arches (J,K), mab21l1 has increased in the tectum (J2,K2). Arrowheads (A,B,A2,B2), optic vesicles; arrows (A,B,A2,B2), tectum; arrow (D,E,D2,E2), olfactory bulbs; a, amacrine cells; d, dorsal; g, ganglion cells; v, ventral; tr, temporal retina; nr, nasal retina; l, lens; tm, tectum; hb, hindbrain; ov, otic vesicle; ba, branchial arches; e, eye; cmz, ciliary marginal zone. A,D,G,J,A2,D2,G2,J2: dorsal and B,C,E,F,H,I,K,B2,C2,E2,F2,H2,I2,K2: lateral views.