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ZFIN ID: ZDB-FIG-110622-21
Cederlund et al., 2011 - mab21l2 transgenics reveal novel expression patterns of mab21l1 and mab21l2, and conserved promoter regulation without sequence conservation. Developmental dynamics : an official publication of the American Association of Anatomists   240(4):745-754 Full text @ Dev. Dyn.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage Range: 1-4 somites to Day 5

Fig. 3

Developmental expression of mab21l1 and mab21l2. At <11 hpf, mab21l2 and mab21l1 are expressed in optic vesicles and tectum (A,B, A2,B2). At <24 hpf, mab21l2, but not mab21l1, is expressed in the lens (C,C2), and only mab21l1 is expressed in olfactory bulbs (D,E, D2,E2). mab21l1 is detected throughout the retina (C2), mab21l2 is confined to the inner retina (C, dots: retina) and both are expressed in tectum and hindbrain (D, D2). At <3 dpf, mab21l1 is expressed in ganglion and amacrine cells (F2), retinal mab21l2 is confined to cells proximal to the lens (F). In the tectum, mab21l1 is widely expressed (G2,H2), whereas only the posterior region expresses mab21l2 (G,H). In the hindbrain, mab21l1 is strongly expressed in the anterior region (G2,H2); mab21l2 is expressed throughout (G2,H2). In branchial arches, mab21l2 is expressed along all craniofacial processes (H); mab21l1 is confined to regions close to the otic vesicle (H2). At 5 dpf, mab21l1 remains expressed in amacrine and ganglion cells, but is downregulated in a ventral patch where mab21l2 is confined (I,I2). mab21l2 expression appears unchanged in the brain but reduced in branchial arches (J,K), mab21l1 has increased in the tectum (J2,K2). Arrowheads (A,B,A2,B2), optic vesicles; arrows (A,B,A2,B2), tectum; arrow (D,E,D2,E2), olfactory bulbs; a, amacrine cells; d, dorsal; g, ganglion cells; v, ventral; tr, temporal retina; nr, nasal retina; l, lens; tm, tectum; hb, hindbrain; ov, otic vesicle; ba, branchial arches; e, eye; cmz, ciliary marginal zone. A,D,G,J,A2,D2,G2,J2: dorsal and B,C,E,F,H,I,K,B2,C2,E2,F2,H2,I2,K2: lateral views.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
mab21l1 WT control 1-4 somites midbrain neural keel ISH
1-4 somites optic primordium ISH
Prim-5 hindbrain ISH
Prim-5 neural tube ISH
Prim-5 olfactory system ISH
Prim-5 optic cup ISH
Prim-5 optic tectum ISH
Protruding-mouth amacrine cell ISH
Protruding-mouth hindbrain ISH
Protruding-mouth optic tectum ISH
Protruding-mouth pharyngeal arch 3-7 ISH
Protruding-mouth retina ISH
Protruding-mouth retinal ganglion cell ISH
Day 5 amacrine cell ISH
Day 5 hindbrain ISH
Day 5 optic tectum ISH
Day 5 pharyngeal arch 3-7 ISH
Day 5 retinal ganglion cell ISH
mab21l2 WT control 1-4 somites midbrain neural keel ISH
1-4 somites optic primordium ISH
Prim-5 hindbrain ISH
Prim-5 neural tube ISH
Prim-5 optic cup ISH
Prim-5 optic tectum ISH
Prim-5 solid lens vesicle ISH
Protruding-mouth eye ISH
Protruding-mouth hindbrain ISH
Protruding-mouth mandibular arch skeleton ISH
Protruding-mouth optic tectum posterior region ISH
Protruding-mouth pectoral fin ISH
Protruding-mouth pharyngeal arch 3-7 ISH
Day 5 eye ISH
Day 5 hindbrain ISH
Day 5 optic tectum ISH
Day 5 pharyngeal arch 3-7 ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal Developmental dynamics : an official publication of the American Association of Anatomists for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Dev. Dyn.